Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.6
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Theanine
200 mg
*
Inositol
100 mg
*
Top Medical Research Studies
9.5
We examined the effects of L-theanine, a natural amino acid, on heart health during a condition known as ischemia-reperfusion (I/R) injury. In our study with rats, we found that L-theanine significantly improved heart function after I/R stress. It reduced oxidative damage and preserved mitochondrial health, indicating that it promotes antioxidant defenses in cardiac tissue. By enhancing the activity of important antioxidant enzymes and adjusting gene expression, L-theanine appears to provide vital protection against heart injury. However, further research is required to solidify L-theanine's role in heart disease treatment.
Read More
9
We investigated how l-theanine, found in green tea, affects neointimal hyperplasia, a key issue during heart stent procedures. Our research used a rat model to assess its impact, revealing that l-theanine significantly reduced neointimal formation and inhibited harmful changes in vascular smooth muscle cells.
In laboratory tests, l-theanine effectively curtailed cell growth and mobility related to heart disease, showing promise as a potential treatment. This study highlights l-theanine's role in improving vascular health and suggests it could be a beneficial option for heart disease management.
In laboratory tests, l-theanine effectively curtailed cell growth and mobility related to heart disease, showing promise as a potential treatment. This study highlights l-theanine's role in improving vascular health and suggests it could be a beneficial option for heart disease management.
Read More
8
We investigated how L-theanine, an amino acid found in tea, can help protect the heart from damage caused by restricted blood flow and subsequent restoration, known as myocardial ischemia-reperfusion injury (MIRI).
Our research on mice showed that L-theanine reduces harmful oxidative stress and cell death in heart tissue, largely through a specific signaling pathway called JAK2/STAT3.
While results are promising, it highlights a potential direction for developing treatments to safeguard heart health, but further studies are needed to confirm its effectiveness in humans.
Our research on mice showed that L-theanine reduces harmful oxidative stress and cell death in heart tissue, largely through a specific signaling pathway called JAK2/STAT3.
While results are promising, it highlights a potential direction for developing treatments to safeguard heart health, but further studies are needed to confirm its effectiveness in humans.
Read More
Most Useful Reviews
9
Anxiety alleviation
1 people found this helpful
L-theanine has greatly helped with my anxiety. Previously, my heart would race uncontrollably in stressful situations, but now I feel much calmer and can approach my day without that constant stress.
Read More
9
Calmer responses
1 people found this helpful
I enjoy a cup of coffee with an L-theanine capsule each morning. This combination significantly reduces my jitters and heart palpitations while enhancing my mood and clarity.
Read More
9
Blood pressure normalisation
1 people found this helpful
As I manage a stressful job, taking this product with magnesium at night has normalised my blood pressure and heart health during check-ups.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.6
- All Researches
9.5
We examined the effects of L-theanine, a natural amino acid, on heart health during a condition known as ischemia-reperfusion (I/R) injury. In our study with rats, we found that L-theanine significantly improved heart function after I/R stress. It reduced oxidative damage and preserved mitochondrial health, indicating that it promotes antioxidant defenses in cardiac tissue. By enhancing the activity of important antioxidant enzymes and adjusting gene expression, L-theanine appears to provide vital protection against heart injury. However, further research is required to solidify L-theanine's role in heart disease treatment.
Read More
9
We investigated how l-theanine, found in green tea, affects neointimal hyperplasia, a key issue during heart stent procedures. Our research used a rat model to assess its impact, revealing that l-theanine significantly reduced neointimal formation and inhibited harmful changes in vascular smooth muscle cells.
In laboratory tests, l-theanine effectively curtailed cell growth and mobility related to heart disease, showing promise as a potential treatment. This study highlights l-theanine's role in improving vascular health and suggests it could be a beneficial option for heart disease management.
In laboratory tests, l-theanine effectively curtailed cell growth and mobility related to heart disease, showing promise as a potential treatment. This study highlights l-theanine's role in improving vascular health and suggests it could be a beneficial option for heart disease management.
Read More
9
Our study aimed to understand how inositol supplementation could help combat heart issues caused by lithium in mice. We examined four groups of C57BL6 mice, some of which received lithium for eight weeks, while others either received inositol during or after the lithium treatment. We specifically looked at various heart functions, structures, and how the heart cells responded to stress.
We found that inositol has a significant protective effect on the heart. Mice that received inositol, either during or after lithium exposure, showed improvements in heart size, function, and electrical stability. For example, the inositol group had reduced heart cell swelling and better performance during stress tests. Overall, these findings suggest that inositol could serve as a beneficial strategy for managing lithium-induced cardiac issues.
Furthermore, the inositol treatment appeared to reverse changes associated with heart muscle enlargement and helped stabilize the expression of certain proteins critical for heart function. In contrast, untreated mice displayed increased cardiac dysfunction and other organ issues. Overall, the study underscores inositol's promise as a potential treatment for heart-related side effects arising from lithium use.
We found that inositol has a significant protective effect on the heart. Mice that received inositol, either during or after lithium exposure, showed improvements in heart size, function, and electrical stability. For example, the inositol group had reduced heart cell swelling and better performance during stress tests. Overall, these findings suggest that inositol could serve as a beneficial strategy for managing lithium-induced cardiac issues.
Furthermore, the inositol treatment appeared to reverse changes associated with heart muscle enlargement and helped stabilize the expression of certain proteins critical for heart function. In contrast, untreated mice displayed increased cardiac dysfunction and other organ issues. Overall, the study underscores inositol's promise as a potential treatment for heart-related side effects arising from lithium use.
Read More
8
We investigated how L-theanine, an amino acid found in tea, can help protect the heart from damage caused by restricted blood flow and subsequent restoration, known as myocardial ischemia-reperfusion injury (MIRI).
Our research on mice showed that L-theanine reduces harmful oxidative stress and cell death in heart tissue, largely through a specific signaling pathway called JAK2/STAT3.
While results are promising, it highlights a potential direction for developing treatments to safeguard heart health, but further studies are needed to confirm its effectiveness in humans.
Our research on mice showed that L-theanine reduces harmful oxidative stress and cell death in heart tissue, largely through a specific signaling pathway called JAK2/STAT3.
While results are promising, it highlights a potential direction for developing treatments to safeguard heart health, but further studies are needed to confirm its effectiveness in humans.
Read More
8
ITPP shows promise in heart health
We explored the effects of myo-inositol trispyrophosphate (ITPP) on heart disease, particularly in the context of pulmonary hypertension (PH). The study involved injecting rats with monocrotaline, which induces PH, and then administering either ITPP or a placebo over five weeks. Through careful monitoring techniques, including echocardiograms and pressure-volume loops, we aimed to see whether ITPP could alleviate the negative impacts of PH on the heart.
Our findings revealed that ITPP indeed reduced mortality associated with PH. While it didn't change the rise in pulmonary vascular resistance, it significantly improved heart function by relieving hypoxia in the right ventricle (RV). This relief was tied to a decrease in RV wall stress, enhancing the heart’s ability to pump effectively under strain. Additionally, we noted that ITPP may help prevent some changes associated with oxygen deprivation, although it did not affect capillary density in the heart.
The implications of our research suggest that enhancing oxygen delivery to the right ventricle could be a valuable addition to existing treatments for PH. ITPP stands out as a promising candidate that could help the heart better manage the increased pressure it faces in these conditions, ultimately improving survival rates.
Our findings revealed that ITPP indeed reduced mortality associated with PH. While it didn't change the rise in pulmonary vascular resistance, it significantly improved heart function by relieving hypoxia in the right ventricle (RV). This relief was tied to a decrease in RV wall stress, enhancing the heart’s ability to pump effectively under strain. Additionally, we noted that ITPP may help prevent some changes associated with oxygen deprivation, although it did not affect capillary density in the heart.
The implications of our research suggest that enhancing oxygen delivery to the right ventricle could be a valuable addition to existing treatments for PH. ITPP stands out as a promising candidate that could help the heart better manage the increased pressure it faces in these conditions, ultimately improving survival rates.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Anxiety alleviation
1 people found this helpful
L-theanine has greatly helped with my anxiety. Previously, my heart would race uncontrollably in stressful situations, but now I feel much calmer and can approach my day without that constant stress.
Read More
9
Calmer responses
1 people found this helpful
I enjoy a cup of coffee with an L-theanine capsule each morning. This combination significantly reduces my jitters and heart palpitations while enhancing my mood and clarity.
Read More
9
Blood pressure normalisation
1 people found this helpful
As I manage a stressful job, taking this product with magnesium at night has normalised my blood pressure and heart health during check-ups.
Read More
0
Heart palpitations risk
1 people found this helpful
I experienced severe ectopic heartbeats and rapid heart rate after taking the recommended 200mg dose for a week. It was frightening, and I nearly went to the hospital until I realised what was causing it. I found many accounts online of others having the same reaction. I believe there should be a warning on the bottle about the risks related to heart disease. I will not use it again.
Read More
0
Anxiety increase
It caused me anxiety and heart palpitations. I won't purchase it again.
Read More
Frequently Asked Questions
7.5
Miraculous pulse reduction
12 people found this helpful
After my mother's passing, I sought something soothing and settled on L-theanine. Its calming effects have been wonderful. Also, it remarkably reduced my historically high pulse rate down to 75-85 within two days. I encourage others facing similar issues to give it a try.
7.5
Reduced anxiety
After taking L-theanine for a week, I've experienced a reduction in anxiety and improved focus without daytime drowsiness, positively impacting my heart health.
0
Heart palpitations risk
1 people found this helpful
I experienced severe ectopic heartbeats and rapid heart rate after taking the recommended 200mg dose for a week. It was frightening, and I nearly went to the hospital until I realised what was causing it. I found many accounts online of others having the same reaction. I believe there should be a warning on the bottle about the risks related to heart disease. I will not use it again.
9
Anxiety alleviation
1 people found this helpful
L-theanine has greatly helped with my anxiety. Previously, my heart would race uncontrollably in stressful situations, but now I feel much calmer and can approach my day without that constant stress.
9
Calmer responses
1 people found this helpful
I enjoy a cup of coffee with an L-theanine capsule each morning. This combination significantly reduces my jitters and heart palpitations while enhancing my mood and clarity.
0
Unpleasant effects
1 people found this helpful
It's not suitable for me. My head hurts, and my heart is pounding, making it difficult to concentrate. I advise against it for those sensitive to heart disease.
9
Blood pressure normalisation
1 people found this helpful
As I manage a stressful job, taking this product with magnesium at night has normalised my blood pressure and heart health during check-ups.
9
Sleep improvement
I've noticed better sleep quality and normalised pulse rates since taking L-theanine with bacopa at night; it really calms my heart.
9
Calms heart palpitations
4 people found this helpful
L-theanine effectively calms the heart palpitations I experience due to stress and mood swings. It has become a vital aid in managing my emotional state, and I regard it as a helpful remedy.
7.5
Calming effect
When feeling irritable, depressed, particularly with pounding heart or anxiety, I find this helps me feel calm. I divide the dose between morning and afternoon meals and sometimes take it with coffee.
8
We investigated how L-theanine, an amino acid found in tea, can help protect the heart from damage caused by restricted blood flow and subsequent restoration, known as myocardial ischemia-reperfusion injury (MIRI).
Our research on mice showed that L-theanine reduces harmful oxidative stress and cell death in heart tissue, largely through a specific signaling pathway called JAK2/STAT3.
While results are promising, it highlights a potential direction for developing treatments to safeguard heart health, but further studies are needed to confirm its effectiveness in humans.
Our research on mice showed that L-theanine reduces harmful oxidative stress and cell death in heart tissue, largely through a specific signaling pathway called JAK2/STAT3.
While results are promising, it highlights a potential direction for developing treatments to safeguard heart health, but further studies are needed to confirm its effectiveness in humans.
9.5
We examined the effects of L-theanine, a natural amino acid, on heart health during a condition known as ischemia-reperfusion (I/R) injury. In our study with rats, we found that L-theanine significantly improved heart function after I/R stress. It reduced oxidative damage and preserved mitochondrial health, indicating that it promotes antioxidant defenses in cardiac tissue. By enhancing the activity of important antioxidant enzymes and adjusting gene expression, L-theanine appears to provide vital protection against heart injury. However, further research is required to solidify L-theanine's role in heart disease treatment.
9
Our study aimed to understand how inositol supplementation could help combat heart issues caused by lithium in mice. We examined four groups of C57BL6 mice, some of which received lithium for eight weeks, while others either received inositol during or after the lithium treatment. We specifically looked at various heart functions, structures, and how the heart cells responded to stress.
We found that inositol has a significant protective effect on the heart. Mice that received inositol, either during or after lithium exposure, showed improvements in heart size, function, and electrical stability. For example, the inositol group had reduced heart cell swelling and better performance during stress tests. Overall, these findings suggest that inositol could serve as a beneficial strategy for managing lithium-induced cardiac issues.
Furthermore, the inositol treatment appeared to reverse changes associated with heart muscle enlargement and helped stabilize the expression of certain proteins critical for heart function. In contrast, untreated mice displayed increased cardiac dysfunction and other organ issues. Overall, the study underscores inositol's promise as a potential treatment for heart-related side effects arising from lithium use.
We found that inositol has a significant protective effect on the heart. Mice that received inositol, either during or after lithium exposure, showed improvements in heart size, function, and electrical stability. For example, the inositol group had reduced heart cell swelling and better performance during stress tests. Overall, these findings suggest that inositol could serve as a beneficial strategy for managing lithium-induced cardiac issues.
Furthermore, the inositol treatment appeared to reverse changes associated with heart muscle enlargement and helped stabilize the expression of certain proteins critical for heart function. In contrast, untreated mice displayed increased cardiac dysfunction and other organ issues. Overall, the study underscores inositol's promise as a potential treatment for heart-related side effects arising from lithium use.
8
ITPP shows promise in heart health
We explored the effects of myo-inositol trispyrophosphate (ITPP) on heart disease, particularly in the context of pulmonary hypertension (PH). The study involved injecting rats with monocrotaline, which induces PH, and then administering either ITPP or a placebo over five weeks. Through careful monitoring techniques, including echocardiograms and pressure-volume loops, we aimed to see whether ITPP could alleviate the negative impacts of PH on the heart.
Our findings revealed that ITPP indeed reduced mortality associated with PH. While it didn't change the rise in pulmonary vascular resistance, it significantly improved heart function by relieving hypoxia in the right ventricle (RV). This relief was tied to a decrease in RV wall stress, enhancing the heart’s ability to pump effectively under strain. Additionally, we noted that ITPP may help prevent some changes associated with oxygen deprivation, although it did not affect capillary density in the heart.
The implications of our research suggest that enhancing oxygen delivery to the right ventricle could be a valuable addition to existing treatments for PH. ITPP stands out as a promising candidate that could help the heart better manage the increased pressure it faces in these conditions, ultimately improving survival rates.
Our findings revealed that ITPP indeed reduced mortality associated with PH. While it didn't change the rise in pulmonary vascular resistance, it significantly improved heart function by relieving hypoxia in the right ventricle (RV). This relief was tied to a decrease in RV wall stress, enhancing the heart’s ability to pump effectively under strain. Additionally, we noted that ITPP may help prevent some changes associated with oxygen deprivation, although it did not affect capillary density in the heart.
The implications of our research suggest that enhancing oxygen delivery to the right ventricle could be a valuable addition to existing treatments for PH. ITPP stands out as a promising candidate that could help the heart better manage the increased pressure it faces in these conditions, ultimately improving survival rates.
References
- Li Q, Ding J, Xia B, Liu K, Zheng K, et al. L-theanine alleviates myocardial ischemia/reperfusion injury by suppressing oxidative stress and apoptosis through activation of the JAK2/STAT3 pathway in mice. Mol Med. 2024;30:98. doi:10.1186/s10020-024-00865-0
- García-Niño WR, Correa F, Zúñiga-Muñoz AM, José-Rodríguez A, Castañeda-Gómez P, et al. L-theanine abates oxidative stress and mitochondrial dysfunction in myocardial ischemia-reperfusion injury by positively regulating the antioxidant response. Toxicol Appl Pharmacol. 2024;486:116940. doi:10.1016/j.taap.2024.116940
- Bi A, Hang Q, Huang Y, Zheng S, Bi X, et al. l-Theanine attenuates neointimal hyperplasia via suppression of vascular smooth muscle cell phenotypic modulation. J Nutr Biochem. 2020;82:108398. doi:10.1016/j.jnutbio.2020.108398
- L'Abbate S, Nicolini G, Forini F, Lepore E, Marchetti S, et al. Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice. Biomed Pharmacother. 2024;178:117287. doi:10.1016/j.biopha.2024.117287
- Oknińska M, Paterek A, Grzanka M, Zajda K, Surzykiewicz M, et al. Myo-inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline-induced pulmonary hypertension in the rat. Br J Pharmacol. 2024;181:4050. doi:10.1111/bph.16482
- Fu L, Du J, Furkert D, Shipton ML, Liu X, et al. Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin. Cardiovasc Res. 2024;120:954. doi:10.1093/cvr/cvae017
