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SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 25 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Theanine
200 mg
*
Inositol
100 mg
*
Top Medical Research Studies
8
Inositol boosts heart protective adiponectin
Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin.
High relevance to heart disease treatment.
Our research focused on understanding how inositol, specifically a molecule called 5-InsP7, plays a role in heart health by influencing levels of a substance called adiponectin. Adiponectin is important because it helps protect against cardiovascular issues and metabolic disorders.
We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.
When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.
The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.
Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.
We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.
When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.
The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.
Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.
Read More
9
Inositol counters lithium heart damage
Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice.
Directly explores inositol effects
Our study aimed to understand how inositol supplementation could help combat heart issues caused by lithium in mice. We examined four groups of C57BL6 mice, some of which received lithium for eight weeks, while others either received inositol during or after the lithium treatment. We specifically looked at various heart functions, structures, and how the heart cells responded to stress.
We found that inositol has a significant protective effect on the heart. Mice that received inositol, either during or after lithium exposure, showed improvements in heart size, function, and electrical stability. For example, the inositol group had reduced heart cell swelling and better performance during stress tests. Overall, these findings suggest that inositol could serve as a beneficial strategy for managing lithium-induced cardiac issues.
Furthermore, the inositol treatment appeared to reverse changes associated with heart muscle enlargement and helped stabilize the expression of certain proteins critical for heart function. In contrast, untreated mice displayed increased cardiac dysfunction and other organ issues. Overall, the study underscores inositol's promise as a potential treatment for heart-related side effects arising from lithium use.
We found that inositol has a significant protective effect on the heart. Mice that received inositol, either during or after lithium exposure, showed improvements in heart size, function, and electrical stability. For example, the inositol group had reduced heart cell swelling and better performance during stress tests. Overall, these findings suggest that inositol could serve as a beneficial strategy for managing lithium-induced cardiac issues.
Furthermore, the inositol treatment appeared to reverse changes associated with heart muscle enlargement and helped stabilize the expression of certain proteins critical for heart function. In contrast, untreated mice displayed increased cardiac dysfunction and other organ issues. Overall, the study underscores inositol's promise as a potential treatment for heart-related side effects arising from lithium use.
Read More
8
ITPP shows promise in heart health
Myo-inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline-induced pulmonary hypertension in the rat.
Strong relevance to heart disease
We explored the effects of myo-inositol trispyrophosphate (ITPP) on heart disease, particularly in the context of pulmonary hypertension (PH). The study involved injecting rats with monocrotaline, which induces PH, and then administering either ITPP or a placebo over five weeks. Through careful monitoring techniques, including echocardiograms and pressure-volume loops, we aimed to see whether ITPP could alleviate the negative impacts of PH on the heart.
Our findings revealed that ITPP indeed reduced mortality associated with PH. While it didn't change the rise in pulmonary vascular resistance, it significantly improved heart function by relieving hypoxia in the right ventricle (RV). This relief was tied to a decrease in RV wall stress, enhancing the heart’s ability to pump effectively under strain. Additionally, we noted that ITPP may help prevent some changes associated with oxygen deprivation, although it did not affect capillary density in the heart.
The implications of our research suggest that enhancing oxygen delivery to the right ventricle could be a valuable addition to existing treatments for PH. ITPP stands out as a promising candidate that could help the heart better manage the increased pressure it faces in these conditions, ultimately improving survival rates.
Our findings revealed that ITPP indeed reduced mortality associated with PH. While it didn't change the rise in pulmonary vascular resistance, it significantly improved heart function by relieving hypoxia in the right ventricle (RV). This relief was tied to a decrease in RV wall stress, enhancing the heart’s ability to pump effectively under strain. Additionally, we noted that ITPP may help prevent some changes associated with oxygen deprivation, although it did not affect capillary density in the heart.
The implications of our research suggest that enhancing oxygen delivery to the right ventricle could be a valuable addition to existing treatments for PH. ITPP stands out as a promising candidate that could help the heart better manage the increased pressure it faces in these conditions, ultimately improving survival rates.
Read More
Most Useful Reviews
9.5
Anxiety alleviation
L-theanine has greatly helped with my anxiety. Previously, my heart would race uncontrollably in stressful situations, but now I feel much calmer and can approach my day without that constant stress.
Read More
9.5
Calmer responses
I enjoy a cup of coffee with an L-theanine capsule each morning. This combination significantly reduces my jitters and heart palpitations while enhancing my mood and clarity.
Read More
8.3
Blood pressure normalisation
As I manage a stressful job, taking this product with magnesium at night has normalised my blood pressure and heart health during check-ups.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
9
Inositol counters lithium heart damage
Oral supplementation of inositols effectively recovered lithium-induced cardiac dysfunctions in mice.
Directly explores inositol effects
Our study aimed to understand how inositol supplementation could help combat heart issues caused by lithium in mice. We examined four groups of C57BL6 mice, some of which received lithium for eight weeks, while others either received inositol during or after the lithium treatment. We specifically looked at various heart functions, structures, and how the heart cells responded to stress.
We found that inositol has a significant protective effect on the heart. Mice that received inositol, either during or after lithium exposure, showed improvements in heart size, function, and electrical stability. For example, the inositol group had reduced heart cell swelling and better performance during stress tests. Overall, these findings suggest that inositol could serve as a beneficial strategy for managing lithium-induced cardiac issues.
Furthermore, the inositol treatment appeared to reverse changes associated with heart muscle enlargement and helped stabilize the expression of certain proteins critical for heart function. In contrast, untreated mice displayed increased cardiac dysfunction and other organ issues. Overall, the study underscores inositol's promise as a potential treatment for heart-related side effects arising from lithium use.
We found that inositol has a significant protective effect on the heart. Mice that received inositol, either during or after lithium exposure, showed improvements in heart size, function, and electrical stability. For example, the inositol group had reduced heart cell swelling and better performance during stress tests. Overall, these findings suggest that inositol could serve as a beneficial strategy for managing lithium-induced cardiac issues.
Furthermore, the inositol treatment appeared to reverse changes associated with heart muscle enlargement and helped stabilize the expression of certain proteins critical for heart function. In contrast, untreated mice displayed increased cardiac dysfunction and other organ issues. Overall, the study underscores inositol's promise as a potential treatment for heart-related side effects arising from lithium use.
Read More
8
ITPP shows promise in heart health
Myo-inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline-induced pulmonary hypertension in the rat.
Strong relevance to heart disease
We explored the effects of myo-inositol trispyrophosphate (ITPP) on heart disease, particularly in the context of pulmonary hypertension (PH). The study involved injecting rats with monocrotaline, which induces PH, and then administering either ITPP or a placebo over five weeks. Through careful monitoring techniques, including echocardiograms and pressure-volume loops, we aimed to see whether ITPP could alleviate the negative impacts of PH on the heart.
Our findings revealed that ITPP indeed reduced mortality associated with PH. While it didn't change the rise in pulmonary vascular resistance, it significantly improved heart function by relieving hypoxia in the right ventricle (RV). This relief was tied to a decrease in RV wall stress, enhancing the heart’s ability to pump effectively under strain. Additionally, we noted that ITPP may help prevent some changes associated with oxygen deprivation, although it did not affect capillary density in the heart.
The implications of our research suggest that enhancing oxygen delivery to the right ventricle could be a valuable addition to existing treatments for PH. ITPP stands out as a promising candidate that could help the heart better manage the increased pressure it faces in these conditions, ultimately improving survival rates.
Our findings revealed that ITPP indeed reduced mortality associated with PH. While it didn't change the rise in pulmonary vascular resistance, it significantly improved heart function by relieving hypoxia in the right ventricle (RV). This relief was tied to a decrease in RV wall stress, enhancing the heart’s ability to pump effectively under strain. Additionally, we noted that ITPP may help prevent some changes associated with oxygen deprivation, although it did not affect capillary density in the heart.
The implications of our research suggest that enhancing oxygen delivery to the right ventricle could be a valuable addition to existing treatments for PH. ITPP stands out as a promising candidate that could help the heart better manage the increased pressure it faces in these conditions, ultimately improving survival rates.
Read More
8
Inositol boosts heart protective adiponectin
Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin.
High relevance to heart disease treatment.
Our research focused on understanding how inositol, specifically a molecule called 5-InsP7, plays a role in heart health by influencing levels of a substance called adiponectin. Adiponectin is important because it helps protect against cardiovascular issues and metabolic disorders.
We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.
When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.
The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.
Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.
We discovered that the enzyme inositol hexakisphosphate kinase 1 (IP6K1) produces 5-InsP7, which helps regulate how much adiponectin is available in the bloodstream. This regulation occurs through a process that ensures adiponectin stays stable instead of degrading within the cells.
When we decreased the levels of 5-InsP7—either by knocking out the gene responsible for producing it or through specific drug treatments—we noticed a significant increase in adiponectin levels in the plasma. This increase particularly favored the high molecular weight forms of adiponectin, which are particularly beneficial for heart protection.
The findings suggest that targeting 5-InsP7 could be a promising strategy for enhancing adiponectin levels, potentially offering a new avenue for protecting the heart against damage from conditions like ischemia-reperfusion injury, which occurs when blood flow returns to the heart after a period of blockage.
Overall, this study gives insight into how inositol treatment might help heart disease, emphasizing the importance of adiponectin in cardiovascular health.
Read More
User Reviews
USERS' SCORE
Good
Based on 25 Reviews
8.2
9.5
Natural calmness achieved
L-theanine has been remarkable for my Seasonal Affective Disorder. After two months, I noticed a difference, feeling calmer and happier without my previous medication. I’ve reduced my Lexapro dose under my doctor’s guidance and now only take L-theanine, which has greatly improved my mood and manageability of stress.
Read More
9.5
Calms heart palpitations
L-theanine effectively calms the heart palpitations I experience due to stress and mood swings. It has become a vital aid in managing my emotional state, and I regard it as a helpful remedy.
9.5
Anxiety alleviation
L-theanine has greatly helped with my anxiety. Previously, my heart would race uncontrollably in stressful situations, but now I feel much calmer and can approach my day without that constant stress.
9.5
Calmer responses
I enjoy a cup of coffee with an L-theanine capsule each morning. This combination significantly reduces my jitters and heart palpitations while enhancing my mood and clarity.
8.8
Reduced heart rate
After my mother's death, I sought something soothing, settling on L-theanine. It brought a peaceful state of mind, unlike sleeping pills I had tried. Most notably, my pulse, which was historically high, dropped to a miraculous 75-85 after two days of use. Those with similar issues should definitely try it.
Read More
